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Skin-/ eye irritation & corrosion

Skin and eye irritations describe temporary inflammations or irritations that are triggered by contact with irritating substances and are usually reversible. In contrast, skin or eye corrosive properties lead to permanent tissue damage, which is usually irreversible. Precise assessments of these properties are crucial in order to minimise risks and meet regulatory requirements.

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Our test portfolio for the following product groups:

Chemicals, agrochemicals, SVHC, biocides

Skin irritation / corrosion

In vitro skin irritation, Reconstructed human epidermis (RHE) test method OECD 439
In vitro skin corrosion, reconstructed human epidermis (RHE) test method OECD 431
In vitro Membrane Barrier Test Method for Skin Corrosion OECD 435
In vivo acute / short term dermal toxicity in rat OECD 402
In vivo acute / short term dermal toxicity in rabbit OECD 404

Eye irritation / corrosion studies

In vitro eye corrosion, Bovine Corneal Opacity and Permeability Test Method (BCOP) OECD 437
In vitro eye corrosion, Isolated Chicken Eye Test Method OECD 438
In vitro eye irritation and corrosion, Reconstructed human Cornea-like Epithelium (RhCE) Test OECD 492
In vitro eye irritation or corrosion, Reconstructed human Cornea-like Epithelium (RHCE) Test OECD 492B
In vitro eye corrosion and sever irritation, Fluorescence leakage test OECD 460
In vivo acute / short term eye corrosion / irritation in rabbit OECD 405

More on chemicals, agrochemicals, SVHC, biocides

Pharmaceuticals

Acute Tox Studies / Six Pack Toxicological Studies

In vivo acute dermal toxicity OECD 402
In vivo acute dermal irritation/corrosion OECD 404
In vitro skin irriation, Reconstructed human epidermis (RHE) test method OECD 439
In vitro skin corrosion, reconstructed human epidermis (RHE) test method OECD 431
In vitro Membrane barrier test method for skin corrosion OECD 435

Medical devices

Irritation or skin irritation test

In vitro skin irritation direct testing or on extract
In vivo skin irritation test on rabbits
Intracutaneous reactivity in animals
Skin sensitisation (DIN EN ISO 10993-10:2014-10) – Local lymph node assay in mice (LLNA) Sensitisation (Magnusson-Kligman maximisation test) – only upon request by authorities / or for FDA

More about medical devices

Please contact us if you require additional or different tests or would like a customized study design!

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